HMB472H1 Chapter Notes -Hypoxemia, Cardiac Output, Stroke Volume

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Published on 15 Apr 2013
School
UTSG
Department
Human Biology
Course
HMB472H1
Professor
Exercise at altitude- chapter 12
Low partial pressure of oxygen at altitude is what limits exercise performance.
The reduced barometric pressure at altitude is referred to as hypobaric environment or simply
hypobaria (low atmospheric pressure).
Low atmospheric pressure also means a lower partial pressure of oxygen which limits pulmonary
diffusion of oxygen from the lungs and oxygen transport to the tissues.
When oxygen delivery to the body tissues is compromised, the result is cellular hypoxia (oxygen
deficiency)
Few negative physiological effects on performance are seen below 1500m
At an elevation, the air always contains 20.93% oxygen, 0.03 carbon dioxide, 79.04% nitrogen.
The pressure that oxygen molecules in the air exert at various altitudes drops proportionally
with decreases in the barometric pressure.
The very low water vapour pressure at high altitudes promotes evaporation of moisture from
the skin surface, because of the high radiant between skin and air, and can lead quickly to
dehydration.
Because the atmosphere in thinner and drier at altitude, solar radiation is more intense at
higher elevations. This effect is magnified when the ground is snow covered.
Altitude causes hypobaric hypoxia, resulting in decreased partial pressures of oxygen
throughout the body.
With acute exposure to altitude a series of adaptations occur in an attempt to minimize the
drop in oxygen delivery to the tissues. Pulmonary ventilation increases, and pulmonary diffusion
is reasonably well maintained; but oxygen transport is slightly impaired because hemoglobin
saturation at altitude is reduced.
The diffusion gradient that allows oxygen exchange between the blood and active tissue is
substantially reduced at moderate and high altitudes; thus, oxygen uptake by muscle is
impaired. A decrease in plasma volume initially increases red blood cell concentration, allowing
more oxygen to be transported per unit of blood, partially compensating for this impaired
oxygen uptake.
Upon initial ascent to altitude, the body increases its cardiac output during submaximal work to
compensate for the decreased oxygen content per liter of blood. It does so by increasing heart
rate, because stroke volume falls with the fall in plasma volume.
During maximal work at altitude, stroke volume and heart rate are both lower, which reduces
cardiac output. The reduced cardiac output, combined with the decreased pressure gradient,
severely impairs oxygen delivery and uptake.
Ascent to altitude increases metabolic rate by increasing sympathetic nervous system activity.
There is an increased reliance on carbohydrate for fuel, both at rest and during submaximal
exercise.
Prolonged endurance performance suffers the most at high altitude because oxidative energy
production is limited.
Maximal oxygen consumption decreases in proportion to the decrease in atmospheric pressure.
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Document Summary

Low partial pressure of oxygen at altitude is what limits exercise performance. The reduced barometric pressure at altitude is referred to as hypobaric environment or simply hypobaria (low atmospheric pressure). Low atmospheric pressure also means a lower partial pressure of oxygen which limits pulmonary diffusion of oxygen from the lungs and oxygen transport to the tissues. When oxygen delivery to the body tissues is compromised, the result is cellular hypoxia (oxygen deficiency) Few negative physiological effects on performance are seen below 1500m. At an elevation, the air always contains 20. 93% oxygen, 0. 03 carbon dioxide, 79. 04% nitrogen. The pressure that oxygen molecules in the air exert at various altitudes drops proportionally with decreases in the barometric pressure. The very low water vapour pressure at high altitudes promotes evaporation of moisture from the skin surface, because of the high radiant between skin and air, and can lead quickly to dehydration.

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