IMM250H1 Chapter Notes - Chapter 6: Intracellular Parasite, Follicular B Helper T Cells, Adaptive Immune System
19 Nov 2018
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6. 1 how the t helper (th) response is ne-tuned to shape the adaptive immune response. Intracellular pathogens: cell-mediated response - ctl useful. Large extracellular pathogens: cytotoxic mediators etc. Th cells provides cytokines for: activation of cytotoxic t cells, activation of b cells and antibodies, recruit of innate cells to site of infection, activation of cells in tissues eg. macrophages. Naive cd4+ t cell - activated by dc: dc provides polarizing cytokines depending on prrs activated. Tells t cells which helper cell to di erentiate into. 3 major subsets + 2 others: th1, th2, th17, follicular th cells (tfh, regulatory th cells (treg) 6. 2 major th subsets and their main defense functions. 6. 2. 1 th1 cells: destruction of intracellular threats intracellular pathogens. Il-12 secreted > t cell di erentiates into th1 cells: produce e ector cytokine ifn , 3 major mechanisms. Macrophage activation, ctl activation, production of antibodies igg: macrophage activation, increased levels of toxic chemical intermediates in phagocytic vesicles.
