IMM250H1 Chapter Notes - Chapter 10: Naive T Cell, Thymocyte, Molecular Mimicry
Document Summary
Sun exposure multiple sclerosis and type 1 diabetes: vitamin d has been shown to have immunoregulatory functions. Infection molecular mimicry (when antimicrobial antibodies react with self macromolecules of very similar molecules structure. T cells must recognize self-mhc molecules to some degree since foreign antigens can only be recognized in combination with these self proteins. Double negative (dn) thymocytes express neither a tcr nor the co- receptors cd4 and cd8. Single positive (sp) once in the medulla, the thymocytes shut off one of their co-receptors (either cd4+ or cd8+) Aire (autoimmune regulator) transcribes tissue antigens. When a naive t cell interacts with its specific antigen in the absence of a co-stimulatory molecule permanent state of unresponsiveness. Any dc cell presenting a self-antigen will do so in the absence of an inflammatory signal, thus will not express the costimulatory molecule b7. Inhibition of t cell responses mediated by tregs.
