PCL200H1 Chapter Notes - Chapter 7: Cannabis Sativa, Cannabinoid Receptor Type 1, Antiemetic
12 Dec 2019
School
Department
Course
Professor
Document Summary
Cannabis sativa the highest concentration of the psychoactive compounds is in the resin that is made by the female plant. Two components that have an effect on the brain - delta-9 tetrahydrocannabinol (thc) and cannabidiol (cbd) Increased risk of schizophrenia when consumed by people younger than 25. Tolerance - to most behavioural and somatic effects including the high" with chronic use: dependence - rarely observes but has been produced experimentally following prolonged intoxication. Two main psychoactive (has effects on brain function) components are thc and cannabidiol. Thc is an agonist of the cb1 receptor. Cannabinoid receptors and endocannabinoids: medical research on the psychoactive effects of thc had led to the discovery of our body"s own endogenous cannabinoid, endocannabinoid. Found at axon terminals of neurons that release glutamate, gaba, acetylcholine, dopamine, norepinephrine and serotonin: most important difference between endocannabinoids and thc is their half-life ecbs are rapidly degraded by several abundant enzymes in the brain and body.
