PCL200H1 Study Guide - Final Guide: Μ-Opioid Receptor, Cannabinoid Receptor Type 1, Atypical Antipsychotic
Document Summary
Based on the chemical structure and electrical charge of the drug. High affinity means the drug is the perfect key to fit in the lock of the receptor. If the drug has high affinity it means it"s probably selective for just that receptor and doesn"t have other receptors acting out. How effective is the drug in its ability to activate or inactivate its receptor. Is this drug able to activate the receptor fully or is it a wimpy activator. Example: drugs that activate mu opioid receptor have same efficacy, just different in potency. Drug potency - how much drug is needed to get an effect. If it has high potency, you only need a small amount to get an effect. E. g. , fentanyl is much more potent than morphine but both do the same thing agonists of mu opioid receptor. Agonist drugs that occupy receptors and activate them.
