PCL102H1 Chapter Notes - Chapter 19-21: Protein Data Bank, Hiv-1 Protease, Structural Genomics

• School: UTSG
• Department: Pharmacology and Toxicology
• Course: PCL102H1
• Professor: Rebecca Laposa

Document Summary

Idenifying drug targets one protein at a ime: Structural genomics helps determine the 3d structure of proteins at fast rate and helps to discover how proteins work and to deine ligands that modulate their funcion. Sgc determines 3d structures on a large scale of targeing human proteins that represent potenial drug targets responsible for between a quarter and half of all structure in the protein data bank; public domain without restricion. Drugs can be used to turn proteins on or of; drugs are small molecules that bind to proteins and modify their acions. Hiv protease normally binds to a protein chain and clips it into two pieces drugs used to treat. Determined 3d structure of fop protein acvri which reveals precise arrangement of its atoms; looked at its surface can see target want to inhibit; in that pocket the drug should lock perfectly;