PSL301H1 Chapter Notes - Chapter 5: Complement Membrane Attack Complex, White Blood Cell, Eosinophil
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PSL301H1 Full Course Notes
T cell: defends body against intracellular pathogen. Cells insert t- cell receptors into their membrane. Binds only to mhc antigen complexes on the surface of an antigen presenting cell. Every nucleated cell of the body had mhc protein on the " Virus are digested and put on mhc i surface. Tc cell encounter them and kill it. Found on the antigen presenting cells; macrophage, b lymph, dendritic. Th cell encounter tham and secret cytokine. Release cytotoxic pore-forming molecule perforin along with granzymes, Granzyme activate an enzyme cascade apoptosis. Do not direct attack pathogen and infected cells. They secrete cytokine activate other cells. Other interleukin: support mast cells and eosinophils. Activity of the complement system: attract leukocyte, act as opsonin, causes degranulation of mast cells form membrane attack complex. Antibodies enhance innate response by acting as opsonin. First few steps similar, but once the virus enter body cell, humoral immunity is not effective.