PSY290H1 Chapter Notes - Chapter 1: Curare, Caudate Nucleus, Urinary Incontinence

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Talked about his early experiences with the navy in present tense. Thought he was 19 (actually 49) and was terrified and confused when looked in the mirror. Condition was a product of long-term alcohol consumption. Condition first described in late 19th century by a russian physician called s. s. korsakoff. There are six major symptoms of korsakoff"s syndrome: Retrograde amnesia (forget old memories), severe memory loss. Confabulation, that is, invented memories which are then taken as true due to gaps in memory sometimes associated with blackouts. Apathy - the patients lose interest in things quickly and generally appear indifferent to change. Damage to the medial thalamus and mammillary bodies (important for episodic memory) of the posterior hypothalamus as well as generalized cerebral atrophy. Deficiency in vitamin b1 (also called thiamine) - tpp is a derivative. Tpp is required in first step of alcohol fermentation.

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