Biochemistry 2280A Chapter Notes - Chapter 9: Immune System, Anaerobic Respiration, Glucosidases
4 Jul 2020
School
Department
Course
Professor
Document Summary
9. 1 glucose transport: glucose entry driven my concentration. Independent of na: normal range of glucose 4-6mm, 4 glucose transporters, glut 1, glut 2, glut 3, and glut 4, glut 2. In liver and pancreatic: high km (~15 mm, liver picks up glucose in proportion to [] in blood. Liver picks up excess glucose and store it: when blood glucose is high, cannot be saturated under normal physiological conditions, captures excess glucose for storage, glut 2 w/ glucokinase -> glucose sensor for insulin release in pancreatic. B-cells: doesn"t respond to insulin, glut 4, adipose tissue + muscle. 9. 2 glycolysis: cytoplasmic pathway converts glucose -> 2 pyruvate. If cell has mitochondria + o2: energy carrier produce is nadh -> can feed into aerobic respiration to make energy for cell. If no mitochondria or o2: glycolysis happens anaerobically, some available energy is lost, alternate, liver used glycolysis -> excess glucose converted to fatty acids for storage.
