Biochemistry 4463G Chapter Notes - Chapter 8: Blood Pressure, Allele Frequency, Scatter Plot
6 Feb 2018
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Chapter 8: complex inheritance of common multifactorial disorders. Multifactorial diseases with complex inheritance can be classified as either: Discrete qualitative traits: disease is either present or absent in the individual: distinguishing between individuals who either have a disease or not, is straightforward, may require some detailed examination or specialized testing to observe manifestations. If an individual falls out of the normal range, multiple retests need to be performed with (cid:272)o(cid:374)sideratio(cid:374) to the perso(cid:374)"s eth(cid:374)i(cid:272)it(cid:455), age, se(cid:454), et(cid:272). Normal distributions are used to obtain the normal range for most quantitative traits. The position of the peak and the width of the curve depends on two quantities: mean ((cid:645), variance ( 2): square of the standard deviation ( ) The curve becomes more skewed with bias towards a certain population characteristic e. g. for systolic blood pressure, older age-groups show a more skewed, asymmetrical curve.
