Biology 1001A Chapter Notes - Chapter 8.3: Cell Plate, Cell Membrane, Tubulin

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Diploid: two copies of each chromosome, 2n. Haploid: one copy of each chromosome, n. Chromosome segregation: equal distribution of daughter chromosomes into daughter cells. Sister chromatids: two identical copies of a chromosome during cell division. Karyotype: complete collection of metaphase chromosomes, arranged according to size and shape. Appear like thin threads under microscope (visible) Nucleolus becomes smaller- shuts down all rna synthesis. Microtubules/mitotic spindle form between centrosomes as they move to opposite ends of the cell (spindle poles) Bundles of spindle microtubules grow from centrosomes towards centre. Some spindle enters former nuclear area, attaches to chromosomes. Kinetochore proteins form on each chromatid at the centromere. Microtubules that do not attach to kinetochores overlap with opposite microtubules: metaphase. Microtubules align chromosomes to the middle (called metaphase plate) Cannot separate until all chromosomes are assembled at spindle midpoint and each sister chromatid is attached to a microtubule: anaphase. Sister chromatids separate and move to opposite poles.

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