Biology 1002B Chapter Notes - Chapter 14: Base Pair, Proteasome, Prolactin
7 Apr 2016
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14. 2b regulation of transcription initiation involves the effects of proteins. Binding to a gene"s promoter and regulatory sites: Repression of transcription: opposition of activators, decrease transcription initiation, various ways in eukaryotes, bind to where activators bind, bind to own site and prevent activators interacting with coactivators, corepressor recruit basically opposite of coactivator multiprotein analogue complexes. Regulatory sequence in enhancers and promoter proximal regions bind a specific regulatory protein: repressors can bind to enhancers and/or promoter proximal region, find net transcription rate. Coordinated regulation of transcription of genes with related functions: prokaryote operons cluster gene regulation together under one operon, no operons on eukaryotes, coordinately regulated genes have same regulatory sequences, one signal transcribes all genes desired simultaneously, e. g. Hormones and steroids: regulate genes for specific functions. Hormone: molecule produced by tissue transported through blood stream to target tissue. Steroids: lipid derived from cholesterol: steroids hormone acts on specific target tissues: tissues have steroid hormone receptors in cytoplasm.
