Biology 1290B Chapter Notes - Chapter 24: Hiv, Immunodeficiency, Viral Envelope
23 Feb 2018
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Immunodeficiency disorder: immune system malfunction or developmental abnormality in function. Primary immunodeficiency: congenital: result of a genetic abnormality, present from birth, rare, more than 70 disorders documented, immune system does not function properly. Secondary immunodeficiency: occurs later in life, often result from immunosuppressive treatments (chemotherapy, radiation therapy, result of infection, acquired immunodeficiency syndrome (aids, caused by human immunodeficiency virus (hiv) Replication of hiv: begins when gp120 proteins contact cd4 receptors present on plasma membrane of host cell, if transmission occurs via sexual intercourse, initial cells encountered are dendritic cells (dcs) an cd4 (helper) Transmission: transmitted via behaviours including, sharing of blood-contaminated needles, unprotected sexual contact or intercourse. Diagnosis: aptima assay (amplifies & detects hiv rna, viral load test (detects hiv rna. During replication, hiv can undergo high rate of error (virus becomes resistant to arv drugs: monotherapy: drug is used singly, antiretroviral therapy (art): three or more drugs used together.
