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Module 2 Notes.docx

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Western University
Physiology 2130

Physiology 2130 Module 2 Online Notes (Sec 2.1 to 2.7) Body Fluids Introduction  Our internal environment is bathed in fluids  Due to homeostasis, the volume of fluid and concentration of ions is closely controlled so our organ systems can function properly Body Fluid Compartments  The body is divided into two major fluid compartments: the intercellular fluid compartment (ICF – inside all cells) and extracellular fluid compartment (ECF – everything outside the cells)  The Extracellular fluid (makes up internal environment of the body) is further divided into the interstitial fluid compartment (fluid directly outside, bathing the cells) and the plasma (watery portion of the blood)  For an average 70 kg (154 lb) person, the total body water (TBW) found in all of these compartments is 42 liters (L), or 11.1 gallons. The ICF contains 28 L (7.4 gallons or 67% of TBW), the interstitial compartment contains 11 L (2.9 gallons or 26.4% of TBW), and the plasma contains 3 L (0.8 gallons or 6.6% of TBW). A Quick Look at Plasma  Plasma is a pale yellow fluid that consists of 92% water and 8% other substances such as proteins, ions, nutrients, gases, and waste products  Plasma is a colloidal solution - a liquid containing substances that do not settle out of solution  Most of the suspended substances are plasma proteins (albumins, globulins, fibrinogen)  Plasma volume remains relatively constant; normally water intake through the digestive tract closely matches water loss through the kidneys, lungs, d
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