PS268 Chapter Notes - Chapter 5: Reuptake, Dosage Form, Semipermeable Membrane
Pharmacokinetics of Drug Action
-pharmacokinetics refers to how drugs move through the body,
Includes:
(1) drug absorption
(2) distribution
(3) metabolism
(4) excretion
ADME
Time Dependent Factors in Drug Actions
The time course of a drug's action depends on:
-how the drug is administered
-how rapidly its absorbed
-how its eliminated from the body
Ffficacy of a drug:
-its ability to produce a desired behavioural effect
-the usual way to obtain a prolonged effect is to take an additional dose at some time after
the first dose has reached its maximum concentration and started to decline
-if doses are taken too close together, the max blood level will increase with each dose and
Document Summary
Pharmacokinetics refers to how drugs move through the body, Includes: (1) drug absorption (2) distribution (3) metabolism (4) excretion. The time course of a drug"s action depends on: Its ability to produce a desired behavioural effect. The usual way to obtain a prolonged effect is to take an additional dose at some time after the first dose has reached its maximum concentration and started to decline. If doses are taken too close together, the max blood level will increase with each dose and can result in cumulative effects. A dosage form for drugs that are released or activated over time. After oral ingestion, the active ingredient is released into body over 6-10 hour period. A large amount of drug is made initially available for absorption and then smaller amounts are released continually for a long period. Gradual release therafter is designed to maintain the same effective dose of the drug even though the drug is being continually deactivated.
