BIOL 2020 Chapter Notes - Chapter 3.0: Alcoholic Liver Disease, Glutathione S-Transferase, Cirrhosis
8 May 2020
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Document Summary
Increases with obesity, female gender: biomarkers- early warning signs of alcoholic liver disease are in development. Transferrin that is deficient in chp and ggt are thought to be early markers of alcoholic liver disease but are not important components of the screening program: genetics plays a role but not 100%. If you follow monozygotic twins, penetrance is 20% for alcoholic liver disease, which is much higher than normal siblings. And people with a deficiency in glutathione transferase and have less protective antioxidants are at higher risk of alcoholic liver disease. It is probably not the caffeine but the other alkaloids that are in the coffee: fatty liver, the first stage in liver pathology for heavy drinkers in fatty liver. After a weekend of heavy drinking, the number of fat in the liver is noticeable. Results from redox imbalance that leads to more lipogenesis than lipid export.
