BIOL 3051 Chapter Notes - Chapter 9.4: Synovial Fluid, Ct Scan, Hyperuricemia
24 Apr 2020
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Officially based on visualization of uric acid crystals in joint fluid by aspiration. In lieu of joint fluid sample, can use clinical triad: inflammatory monoarthritis, elevated. Lab test: high ua level, high leukocytosis (wbc) Long standing gout: x-ray - asymmetric swelling. Physical signs: joint (usually 1 - great toe) is swollen, inflamed, red, and there is sharp pain, occurring at night/early morning. Possible lab tests cbc with differential, urinalysis, renal ultrasound, urine uric acid quantification, serum urate level. Evaluation of hyperuricemia: overproducing versus underexcretion, males: serum levels >416 umol/l, females: serum levels >357 umol/l. Individuals with hyperuricemia who excrete >1000mg of ua/ 24hrs reflect overproducers: over excretion means normal kidney function. They"re excreting enough, to much produced: there is no definite causality between serum uric acid levels gout person with gout can have high or low levels of serum urate.
