BIOL 3051 Chapter Notes - Chapter 12.0: Clarithromycin, Bismuth, Metronidazole

• School: York University
• Department: Biology
• Course: BIOL 3051
• Professor: Hernan Humana

Document Summary

First line in canada bismuth quadruple therapy and clarithromycin triple therapy. Treatment combinations - h. pylori induced pud: quadruple therapy: (**first line**)- no clarithromycin so no resistance, ppi + bismuth subsalicylate/metronidazole/tetracycline, ppi + amoxicillin/clarithromycin/metronidazole. If penicillin resistant, then metronidazole can be replaced for amoxicillin: triple therapy: (**first line**, ppi + amoxicillin/clarithromycin, ppi + metronidazole/clarithromycin, clarithromycin-based concomitant therapy (see chart above, clarithromycin-based sequential therapy (see chart above, clarithromycin-based hybrid (see chart above) Quadruple therapy is prefered for triple therapy because clarithromycin has. Most regimens have multiple antibiotics because h. pylori is a robust. If macrolide resistance use bismuth quadruple therapy. If penicillin allergy and going with triple therapy, replace. Sequential therapy used when clarithromycin is a problem very. Antibiotic side effects nausea, headache, rashes (allergies to antibiotics), Tetracycline (photosensitivity can get a bad reaction if using the. Ppi side effects stomach cramps, reduced appetite, abdominal pain, etc. **need to know the side effects of each drug in the therapy.