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Week 12 pt6.docx

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Department
Biology
Course
BIOL 3120
Professor
All Professors
Semester
Fall

Description
16. The reaction of antibody with antigen generates immune complexes. The formation of antigen- antibody complexes occurs as a normal part of an adaptive immune response. These complexes are recognized by Fc receptors on phagocytes which results in their elimination. But under certain conditions they are not cleared and they are deposited in blood. These conditions include (1) the presence of antigens capable of generating particularly extensive antigen-antibody lattices, (2) a high intrinsic affinity of antigens for particular tissues, (3) the presence of highly charged antigens (which can affect immune complex engulfment) and (4) a compromised phagocytic system. These complexes can interact with Fc receptors on mast cells, neutrophils, and macrophages which results in the release of proinflammatory substances. Immune complexes then move through the capillary walls
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