KINE 3012 Chapter Notes - Chapter 9.11: Protein Kinase, Threonine, Cell Membrane
11 Mar 2018
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Sti(cid:373)ulates a(cid:374)i(cid:373)als cells to sur(cid:448)i(cid:448)e & gro(cid:449: i(cid:374)suli(cid:374) like growth fa(cid:272)tors (cid:894)igf(cid:895) sti(cid:373)ulate (cid:373)a(cid:374)y types of a(cid:374)i(cid:373)al"s (cid:272)ells to survive & grow, igf bind to rtks which activate pi 3-kinase to produce pi(3,4,5)p3. Pip3 recruits 2 protein kinases to membrane via ph domains- akt (protein kinase: & phosphoinositide-dependent protein kinase 1 (pdk1). Figure 15-53 one way in which signalling through pi 3-kinase promotes cell survival. Extracellular signal activates rtk, which recruits & activates pi 3-kinase. Pi 3-kinasse produced pi(3,4,5)p3, which serves as docking site for two serine/threonine kinases with ph domains- akt & pdk1- & brings them into close proximity in plasma membrane. Akt is phosphorylated on serine (by third kinase) which changes conformation & allows akt phosphorylation on threonine by pdk1 which activates akt. Activated akt dissociates from plasma membrane & phosphorylates target proteins. Ex: bad protein hold inactive apoptosis inhibitory protein.
