KINE 3012 Chapter Notes - Chapter 9.9: Ion Channel, Ligand-Gated Ion Channel, Cytosol
11 Mar 2018
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Receptor proteins: extracellular signal molecules bind to specific receptor proteins on surface of target cell. Cell-surface receptors are signal transducers by converting extracellular ligand-binding event into intracellular signals that alter behaviour of target cell. Ion channel coupled receptors (transmitter-gated ion channels or ionotropic receptors: rapid synaptic signalling b/t nerve cells & excitable cells (muscle, mediated by neurotransmitters that open or close ion channels. This changes ion permeability which changes excitability of postsynaptic neuron. Intracellular signals act to change behaviour of another signalling protein. Enzyme coupled: usually single-pass transmembrane proteins. have ligand-binding site outside of cell & catalytic or enzyme binding site inside cell, ex: protein kinases phosphorylate proteins in target cell when activated. Important function in controlling specialization of different cell types during development. Figure 15-4 a(cid:374) a(cid:374)i(cid:373)al"s cell"s depe(cid:374)de(cid:374)ce o(cid:374) (cid:373)ultiple extracellular sig(cid:374)al (cid:373)olecules. Each cell type displays set of receptors that enables its to respond to corresponding set of signal molecules produced by other cells.
