KINE 3012 Chapter Notes - Chapter 8.1: Complex Differential Form, Hydrolysis
11 Mar 2018
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Document Summary
Intracellular signalling complexes form activated receptors: scaffold proteins: bring together groups of interacting signalling proteins into signalling complexes, scaffold holds proteins into close proximity, can interact at high local concentrations & activated rapidly, efficiently to right extracellular signal. In other cases, signalling complex form in response to extracellular signal & rapid disassembly when signal is gone. Relationship b/t signal & reponses varies in different signalling pathways. Intracellular signalling system detects & measures specific stimuli in one location of cell & generates a timed & measures response at another location. This allows to send signal from sensor to target: response timing varies according to speed required for response, synaptic signalling is fast (msecs, hormones act at low concentrations. Targeted are highly sensitive to low concentration of signal: neurotransmitters operate at higher concentration at synapse. Branching of signaling pathways allows one signal to modulate strength of a response to another other signal.
