KINE 3012 Chapter Notes - Chapter 1.3: Electrochemical Gradient, Glucose Transporter, Extracellular Fluid
1 Apr 2018
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From interstitial fluid it diffuses into peritubular capillaries: amount of glucose entering filtrate is proportional to plasma concentration, na+/glucose transporters have potential to limit max rate or reabsorption (transport max) Transport maximum is point where saturated with glucose. Not enough to move glucose completely: na+ enters cell down electrochemical gradient using na+/glucose transporter. Glucose moves against concentration gradient while na+ moves down gradient: glucose diffuses out of cell using glut down conc. Gradient: na+ is pumped to basolateral side of cell by na+/k+ Glucose transport can be saturated: transporters are very efficient reabsorb every glucose molecule until tm is reached, tubular transport maximum: determines by # of transporters & their rate of action, linear indicate direct relationship. Plasma concen. is proportional to reabsorption to plasma: point of plateau is transport maximum. Excess glucose appears in urine: renal threshold: plasma concentration of glucose that results in saturation of transporters.
