PHIL 2015 Chapter Notes - Chapter 5.1: Interstitial Nephritis, Allopurinol, Nephritis
23 May 2020
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Not low (>40), because tubular function craps out. Acute interstitial nephritis (ain) clinical feaures: arf 1-2 weeks post exposure, fever (sometimes, rash (sometimes, eosinophilia (sometimes, urine, oliguria, rbcs, wbcs, occasionally eosinophils, wbc casts indicative of uti. Acute interstitial nephritis causes: drugs, antibiotics sulfas, penicillin, rifampicin, nsaids, phenytoin, cimetidine, ranitidine, allopurinol, infections, legionella, brucella, etc, ebv, cmv, mycoplasma, etc, other, idiopathic. 55 year old woman, well, found to have asymptomatic increase in serum uric acid by family doc. 2 weeks later: fever, unwell, increased bp, fine rash over obdy, increased wbc with eosinophilia, urine: wbc, wbc casts, creatinine = 404 mol/l. 19 year old male, gas station attendant. Hemopytsis (coughing blood), fever, increase bp, edema. Interpretation of case 1: the changes in the kidney are paralelled by changes in the lung. Know the causes of pre-renal, renal, and post-renal insufficiency. Try to ilustrate a patient case proteinuria, nephrotic symdrome, na+ retention, edema. Patients on iron urine will turn darker colour.
