PSC 431 Chapter 2: pharmacodynamics
17 Feb 2019
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Document Summary
Major receptor families: pharmacology defines a receptor as any biologic molecule to which a drug binds and produces a measurable response. Thus, enzymes and structural proteins can be considered to be pharmacologic receptors: however, the richest sources of therapeutically exploitable pharmacologic receptors are proteins that are responsible for transducing extracellular signals into intracellular responses. Stimulation of the nicotinic receptor by acetylcholine results in sodium influx, generation of an action potential, and activation of contraction in skeletal muscle. receptor by gaba, resulting in increased chloride influx and hyperpolarization of the respective cell. Benzodiazepines, on the other hand, enhance the stimulation of the gaba: g protein-coupled receptors. Stimulation of these receptors results in responses that last several seconds to minutes. coming from g protein-coupled receptors. This family of receptors transduces signals derived from odors, light, and numerous neurotransmitters, including norepinephrine, dopamine, serotonin, and acetylcholine. Second messengers: these are essential in conducting and amplifying signals: enzyme-linked receptors.
