BIOL 3200 Chapter Notes - Chapter 12: Prokaryotic Small Ribosomal Subunit, The Perfect Drug, Thiazolidine
Document Summary
Micro chapter 12 antimicrobial chemotherapy: goal of antimicrobial chemotherapy: Administer a drug to an infected person that destroys the infective agent (cid:449)ithout har(cid:373)i(cid:374)g the host"s (cid:272)ells: the perfect drug does not exist, three factors must be known before starting antimicrobial therapy: The overall medical condition of the patient: selective toxicity: Antimicrobial drugs should kill or inhibit microbial cells without simultaneously damaging host tissues. Antibacterial drugs targeting the cell wall: penicillins: Three parts: thiazolidine ring, beta lactam ring, variable side chain, cephalosporin"s: Antibacterial drugs targeting protein synthesis: the aminoglycoside drugs: Side effects: gastrointestinal disruption, deposition in hard tissues, glycylcyclines: Effective against bacteria resistant to tetracyclines: erythromycin: Broad spectrum, low toxicity: clindamycin, telithromycin: Adverse reactions in the gi tract limits its use. Respiratory tract infections suspected to be caused by resistant microbes. Antibacterial drugs targeting folic acid synthesis: sulfonamides or sulfa drugs: Antibacterial drugs targeting dna or rna: fluoroquinolones: Side effects: seizures and other brain disturbances.
