NURS 2060 Chapter Notes - Chapter 18-21, 38,39: Plasmin, Thrombin, Glycosuria
Document Summary
Increases in secretion of erythropoietin (epo: kidneys detects low oxygen, epo stimulates enhanced erythropoiesis in bone marrow. Increased anisocytosis (variation in rbc size: caused by disorders of: Iron metabolism: porphyrin and heme synthesis (porphyrin = red pigment of rbcs and a cofactor of heme, globin synthesis, examples: iron deficiency anemia, normocytic-normochromic anemia, cells are normal, hemoglobin is normal, rbcs number is insufficient, primary causes: Reticulocyte low in aplastic anemia; high with hemorrhage: example: aplastic and hemolytic anemia. Causes of impaired erythrocyte production: altered hemoglobin synthesis, altered dna synthesis, vitamin b and/or folate deficiency, stem cell dysfunction, bone marrow infiltration. Pathophysiology and clinical manifestations of: pernicious anemia, pathophysiology, b12 deficiency, associated with chronic atrophic gastritis (loss stomach cells that make intrinsic factor)) Intrinsic factor is needed to absorb vitamin b12. Problem is not related to intake, problem is related to absorption. Genetics vs. autoimmune gastritis (parietal and zymogenic cells are destroyed)
