BIOL 4246 Chapter : 6 20 12
Document Summary
Repeat: bind aminoacyl trna to a site, transpeptidation, translocation. Until stop codon appears in the a site. When the ribosome stalls, it is possible that a release factor can bind the a site and potentially terminate translation. Release the peptide from the ribosome and then release the ribosome from the mrna. Those are two goals of this process: rf1 or rf2 can bind empty a-site with appropriate stop codon. R2s can bind if uaa or uga is present: they have the same size and shape of aminoacyl trna, l shaped structure associated with the folded trna, binding is aided by rf3. It has the same size and shape as an aminoacyl trna bound by. Rf3 aids in the binding of rf1 or rf2. Biochemically not necessary: once rf1 or rf2 binds the a site it causes peptidyltransferase activity to hydrolyze peptide from the trna in p site.
