BIOL-UA 11 Chapter Notes - Chapter 12-15, 23, 24, 26: Abo Blood Group System, Binomial Distribution, Mutual Exclusivity

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G1: g1: cyclin degradation continues, and cdk component is recycled. G1 checkpoint and division of fibroblasts: density-dependent inhibition: crowded cells stop dividing, binding of cell-surface protein to counterpart on adjoining cell sends signal to inhibit divsion, anchorage dependence: must be attached to substratum to divide. Cancer: make their own growth factors, or have abnormality that conveys growth signal even in absence of that factor, abnormal control system, transformation: process that causes cells divide indefinitely and be cancerous. Inherit one set of chromosomes from each parent: genetic locus represented twice in a diploid cell (once on each homolog) 2 mutations were isolated independently yet had the same phenotype: could not grow on galactose. Single genes: degrees of dominance, complete dominance: dominant allele completely masks recessive allele (dominant homozygote and heterozygote indistinguishable) Recessively inherited: cystic fibrosis, sickle-cell disease: heterozygotes have both normal and sickle cells, and are resistant to malaria.

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