01:119:131 Chapter Notes - Chapter 19: Type Iv Hypersensitivity, Type Iii Hypersensitivity, Mast Cell

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Chapter 19: there are 4 types of hypersensitivities (allergies): immediate type i, cytotoxic type ii, Immune complex type iii and delayed (cell-mediated) type iv. The first 3 involve antibodies while the type iv involves t-cells only. Be able to briefly describe what happens during each type of hypersensitivity. Occurs when someone is sensitive to a foriegn substance (allergen) During the first exposure to the allergen, the person does not have an allergic reaction. Instead, it becomes sensitized to the allergen by creating ige antibodies that attach to basophils and mast cells, During the second exposure, allergen binds to ige mast cells/ basophils release histamine and leukotriene allergic response. Abundance of ige made due to memory cells / existing ige on basophils. Type 2 hypersensitivity: cytotoxic hypersensitivity and mast cells from the first exposure. Antibodies made to whole cells (typically during a wrong blood transfusion) Antibody (anti-a or anti- b) will bind to foriegn antigen (rbc)

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