01:146:356 Chapter Notes - Chapter 23: Tight Junction, Acetyl-Coa, Osteocalcin
23 Mar 2016
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Document Summary
Chapter 23: endocrine control of growth and metabolism: review of endocrine principles. Hypothalamic-pituitary control system, feedback patterns, hormone receptors, cellular responses, modulation of target cell response (up/down regulation), endocrine pathologies (excess secretion, inadequate secretion, abnormal target response: adrenal glucocorticoids. Adrenal medulla is a sympathetic ganglion that releases catecholamines; adrenal cortex secretes variety of steroid hormones. Cbg helps transport cortisol out of adrenal cells. Complex enters nucleus, binds to dna with help of hormone response element and alteration of genes, transcriptions, and translations occurs. Tissue response to glucocorticoids is not evident for hour, but cortisol"s negative feedback effect on acth secretion occurs in minutes. Cortisol is essential for life as it helps in fight or flight situations, protects body against hypoglycemia (link between glucagon and cortisol), cortisol is catabolic o. Exogenous admin of it has negative feedback on anterior pituitary and may shut down acth production adrenal cells may atrophy o. Hypercortisolism: excess gluconeogenesis, tissue wasting, moon face, abdominal fat.
