BIO 327 Chapter Notes - Chapter 18-19: Sister Chromatids, Centromere, Prometaphase

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18 May 2016
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All three filament systems are dynamically regulated to accomplish mitosis and cytokinesis. Different organelles have different mechanisms of transmission to daughter cells: mitochondria/chloroplasts replication and diffusion, er/golgi fragmentation, diffusion/transmission. Dna polymerase works at replication origins: copy or subdivide organelles (mitochondria, peroxisomes, etc. , transmit organelles and nuclear (chromosomes) material equally to daughter cells. Break down of nuclear envelope (lamins and membrane) Set up a division mediator (mitotic spindle: divide the cell itself into two separate cells. Cytokinesis by action of an actin-myosin contractile ring: return to normal business of that cell type (telophase-interphase) Accounts for 95% of cell cycle duration. G-phases: periods of cell-growth: requires series of highly controlled and highly interdependent steps, such control/interdependency requires a complex of signaling and check-point steps, many signals are protein phosphorylation and de-phosphorylation cascades. Dynamics of nuclear lamins are regulated by phosphorylation and de-phosphorylation through the cell cycle.

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