AH 3121 Chapter Notes - Chapter 9: Autoimmune Regulator, Regulatory T Cell, Autoimmune Polyendocrine Syndrome
Document Summary
Self-nonself discrimination in the immune system & its failure. One of the most important features of adaptive immunity. Normally able to discriminate between self and non-self-antigens. Immunological tolerance: recognition of, but unresponsiveness to self-antigens, has to be seen all the time to be tolerated. If tolerance fails the immune system can damage or attack self-cells which is the hallmark of autoimmunity. Lymphocyte activation, tolerance, or ignorance is determined by the nature of: lymphocyte, antigen, how antigen is displayed to the lymphocyte. Maturing lymphocytes are selected at several steps during their maturation. Based on the expression of intact ag receptor components and what the receptors recognize. Some lymphocytes die: death by apoptosis can result when lymphocytes. Do not recognize self-ag at all: both of these are failure of positive selection or, when lymphocytes recognize self-ag with high avidity. Induction of tolerance: most readily induced in immature lymphocytes. Central tolerance (still in the primary lymphoid organ)
