PSYC414 Chapter Notes - Chapter 6: Fear Conditioning, Dorsal Root Of Spinal Nerve, Triptan
6 Mar 2018
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Document Summary
Widespread distribution of 5-ht in the brain variety of behavioral physiological functions. All forebrain regions receive serotonergic innervation (neocortex, striatum, nucleus accumbens, thalamus, hypothalamus, limbic structures such as hc and amg, septal areas) Group of 5 different 5-ht1 receptors (a,b,d,e,f) Additional receptors- 5-ht3,4,5a,5b,6,7) all metabotropic except 5-ht3 (excitatory ionotropic receptor) 5-ht 1b/1d and 5-ht3 subtypes: dilation of blood vessels in brain migraine headaches, triptans (agonists of 1b, 1d) constrict vessels relieve migraine. 5-ht3 located on peripheral terminals of vagus nerve: transmit sensory info from viscera to the brain, responsible for nausea and vomiting in cancer chemotherapy drugs. Methodological approaches: association b/w csf 5-hiaa or postmortem regional brain 5-ht and 5-hiaa concentrations and behavioral traits, assess behavioral, subjective, and physiological responses to challenges with. Ssris or receptor antagonists/agonists identify association b/w d/os and polymorphisms in the genes for sert or various serotonergic receptors. Csf and brain concentrations of 5-hiaa and 5-ht.
