CHEM 342 Chapter Notes - Chapter 22.9-22.10: Nucleophile, Leaving Group, Ammonia
Document Summary
Nucleophilic carbonyl group carbonyl group attack while occurs the becomes part of at one second the leaving o rt te nu nut ho nr r. Anhydride can acyl derivatives because therefore a except is. Rcoo a poorer all chloride stronger base and than a leaving group. 2 3 the leaving group substitution a proton and elimination the amide. Subtitution acid before reaction are strong organic any strong base will react with by removing a any nucleophilic can take place. Carboxylic acid can be converted into cyclic anhydride ester. R c acid chloride acid and chloride amide i. Oh 112804 top o it ester amide of. Carboxylic acids can"t by using be a converted to as a acid chlorides because is nucleophile the attacking nucleophile base the than. Carboxylic acids cannot converted acids can anhydride dehydration water is lost to anhydrides be if converted heated to be readily but dicarboxylic to cyclic high temperature.
