NSC-2201 Chapter Notes - Chapter 5: Autoreceptor, Adenylyl Cyclase, Protein Kinase
1 May 2017
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Intro: process of info transfer at a synapse is synaptic transmission, there are electrical synapses and chemical synapses. Transmitter-gated ion channels: transmitter-gated ion channels open and allow ions to flow when nt binds to specific site on extracellular region of channel, not as selective as voltage-gated channels, epsp: excitatory postsynaptic potential, ipsp: inhibitory postsynaptic potential. Principles of synaptic integration: synaptic integration: process by which multiple synaptic potentials combine within one postsynaptic neuron. Dendritic cable properties: epsp amplitude will diminish because of leakage of ionic current through membrane channels on dendrite, depolarization of membrane at given distance vx can be described by equation. Vx=v0/ex/ : v = 0. 37(v0) depolarization is about 37% that at the origin, called dendritic length constant, value of depends on, 1. Resistance to current flowing longitudinally down dendrite, called internal resistance (ri: 2. Excitable dendrites: most dendrites are passive, most have just enough voltage-gated channels to amplify psps.
