EXSS2028 Lecture Notes - Lecture 5: Fatty Acid Synthase, Phosphoinositide 3-Kinase, Insulin Receptor

• School: University of Sydney
• Department: Exercise and Sport Science
• Course: EXSS2028
• Professor: Kieron Rooney

Document Summary

Fatty acid synthase - converts carbohydrates from excess fat. Pi3 kinase > activation of pkb and pkc. > insulin activates the glut transporters to sit on the membrane. Glut 2 transporter in liver > works better when a large concentration of blood glucose: phosphorylation - insulin receptor activates phosphorylation enzyme for glucose (glucokinase, insulin receptor turn on gs and off gp, storage of glycogen increased. Epinephrine - stress hormone released during exercise - stimulates fuel release. Glucagon - role in sedentary activity/fasting, low role in exercise. Spike in insulin (increase in glycogen and insulin storage) Carbohydrates are best consumed during performance (less ffa available, Epinephrine is inhibited when glucose is available (prevents glycolysis) If you consume carbs during an event, you are only using the carbs you are consuming at that time (not stored carbs, and lower contribution of stored fats) Increased reliance of carbs to fuel demands.