PSIO 303A Lecture Notes - Lecture 6: Glut5, Membrane Transport Protein, Grb2
12 Sep 2016
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Lecture 6 - insulin signaling in skeletal muscle. Understand that disposal of systemic glucose involves: a. b. And understand how insulin regulates both of the above processes. Describe the specific role of insulin receptor signaling and the post-transduction receptor of signals that impact the translocation of glut-4 (glucose transporter) to the sarcolemmal membrane of the myocyte. Know distinguishing features of the glucose transporter family (glut 1-4) and discuss physiological significance for why specific glut isoforms are highly expressed in certain cells and tissues. There are two critical stages of regulation for glucose use by skeletal muscle: Delivery of glucose in the vascular system to skeletal muscle tissue, making it available for transport into myocyte. Transmembrane transport of glucose: from extracellular space of skeletal muscle into cytoplasm of myocyte. Glucose will be metabolized based on endocrine status of organism and energetic needs of muscle. Glucose will also be stored depending on the organ.
