BIOL123 Lecture Notes - Lecture 11: Endoplasmic Reticulum, Endomembrane System, Nuclear Membrane

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7 Aug 2018

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Different membranes are part of the endomembrane: system, nuclear envelope, endoplasmic reticulum, golgi apparatus, peroxisomes, endosomes, plasma membrane. F u n c t i o n: membrane trafficking, production/secretion of secretory products, signalling, membrane cycling. Lecture 11: membrane trafficking: may be stored in secretory granules, released when stimulated, final destination could be internal to the cell, peroxisomes. V es i c l e a s s em b l y. Cytosolic surface of the vesicle normally has a protein coat: helps shape the membrane into a bud, captures molecules for onward transport. Cop-coated vesicle (cid:862)coat protein(cid:863: clathrin coated vesicles, (plasma membrane) Lecture 11: membrane trafficking: copi (golgi apparatus, copii (er membrane) Secretory pathways ship cellular cargo outside of the cell 2 pathways: constitutive exocytosis pathway, continuously happening, regulated exocytosis pathway, only when there is the need. E n d o c y t o s i s r ec ep t o r m ed i a t e d.

Related Questions

Complete the following sentences to examine various components of the endomembrane system.

Information within the ____________ is transcribed into mRNA and transported outside the nuclear envelope.

Proteins, which are synthesized by ____________ , are then released into the ____________ , where they are further folded and modified.

The ____________ does not have attached ____________ and produces lipids, such as steroids.

Once proteins are folded and modified, transport vehicles called ____________ pinch off and surround them with membranes to be transported elsewhere.

The vesicles are moved to the ____________ where they are sorted and packaged.

Transport vehicles called ____________ carry the macromolecules to the ____________ where they fuse and release their contents to the outside environment.

ribosomes

Golgi apparatus

smooth endoplasmic reticulum

vesicles

plasma membrane

rough endoplasmic reticulum

nucleus

secretory vesicles

Which compartments are involved in vesicular transport? How are transport vesicles formed and targeted appropriately? What proteins are involved and what are their roles? What kinds of modifications are added to proteins in the ER? What determines whether a protein stays in the ER or moves on? Be sure to understand how vesicles fuse with their target membranes, and the consequences of fusion for the vesicleâs cargo as well as the proteins and lipids that are in the membrane. Know the structure of the Golgi apparatus and its role in intracellular trafficking. Understand the secretory process, endocytosis, exocytosis, function of the endosomes, and function of the lysosomes. Understand why endocytosis happens and how it can be regulated to take up specific molecules.

One effective learning strategy when trying to learn largeamounts of factual information is to group items, or âchunkâ. Youshould include all important structures of the cell (this includescell membrane and membrane adaptations as well as organelles).Examples of general categories could be location, function,morphology, etc. Your categorization groups must tell the viewersomething about the structures. Once your structures are groupedaccording to the characteristics they share, you should include ashort phrase about what differentiates them from each other withinthe group. Citation of your source material must be present.

List of Organelles:

Nucleus, Nuclear envelope/membrane, Nucleolus, Ribosomes,Endoplasmic reticulum, Golgi apparatus, Mitochondria, Plasmamembrane, Cytoskeleton, Transport/secretory vesicles,Phagosomes/endosomes-including sorting & recycling endosomes,Lysosomes, Peroxisomes, Lipid droplets, Glycogen granules

I started this assignment and was going to go withfunction and morphology. Below is what I have so far, but I'mhaving a difficult time coming up with a short phrase for each anddistinguishing between the organelles that can change shape/morphand those that cannot. I am open to changing the categories that Ihave chosen to chunk. I've never used this technique before so it'sa new concept for me.

Function

Protein Synthesis â Nucleus, Nuclear envelope, Nuclear porecomplex, Ribosomes, Rough endoplasmic reticulum, Golgi apparatus,Plasma membrane

Energy Production â Mitochondria, Lipid droplets, Glycogengranules

Transportation â Transport vesicles, Phagosomes,Cytoskeleton

Metabolism â Lysosomes aid in digestion, Peroxisomes oxidizefatty acids

Morphology

Ability to change shape â Mitochondria, Cell membrane, Nuclearenvelope,

Inability to change shape â Nucleus, Nuclear envelope,

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BIOL123 Lecture Notes - Lecture 11: Endoplasmic Reticulum, Endomembrane System, Nuclear Membrane

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