BIOL 1F25 Lecture Notes - Lecture 10: Design Of Experiments, Tim Hortons, Donald O. Hebb
25 Feb 2016
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Document Summary
Cellular mechanisms of learning and memory (ltp) long-term potentiation. First reported by bliss and lomo in 1973 as an enhancement of synaptic transmission. An increase in strength of a synapse following learning. Synaptic vesicles fuse with membrane and release chemical transmitter. Transmitter bind to receptors on receiving cell and message is transferred: amount of transmitter released can be increased or decreased, amount of receptors present on post synaptic cell can be increased or decreased. Coincident activity in pre and post synaptic cells is critical for strengthening the connection b/w them. Diagram both cells 1 and 3 synapse onto cell 2. Diagram -if cells 1 and 2 are firing action potentials at the same time (but not cell 3): only the connection b/w cells 1 and 2 will be strengthened (and not b/w 3 and 2) How does increased synaptic strength occur: molecular changes, morphological (structural changes) Often studied in ca3 to ca1 pathway in hippocampus.
