BIOL 1F25 Lecture Notes - Lecture 11: Design Of Experiments, Cyclic Adenosine Monophosphate, Memory Consolidation
25 Feb 2016
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Document Summary
Post- synaptic changes: more glutamate receptors put into membrane (ampa type) Both these effects lead to increase in synaptic strength that can last for many hours (i. e, long-term potentiation of synapse) Longer terms changes: ca/ calmodulin activates camp messenger pathway, activates creb (cyclic amp response element binding protein, activates genes to produce long term effects. Activation of genes (nucleus) and new proteins needed. 1: formation of new synapses (increased number of synapses, new dendritic spines formed. Problems w/ involvement of synaptic changes in long-term memory formations: different areas of brain involved in formation vs storage (studies in h. m. , memory reactivation might lead to further changes in those synapses, which eventually lead to memory erosion. Theory: factual memories initially dependent on hippocampus are eventually consolidated in the neocortex. Then reactivation of memories is not purely reactivating the same neurons and synapses that were involved in the initial acquisition of the memory!
