BIOL 1F25 Lecture Notes - Lecture 5: Tracheotomy, Multiple Sclerosis, Riluzole
25 Feb 2016
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Overview: definition, early symptoms, progression, diagnosis, prognosis, treatment. Baseball player: 1st baseman ny yankees 1923-39. Diagnosis confirmed june 19th 1939 (mayo clinic) Early symptoms: fatigue, lack of strength, collapse. Early symptoms: difficulty rowing, fall on stairs, slurred speech. Rare form of als with early onset & slow progress. Nerve cells in spinal core and brain gradually break down and die is slurred. Often begins with muscle twitching and weakness in arm or leg; sometimes speech. Eventually impairs ability to move, speak, eat and breathe. Skeletal atrophy due to lack of neural control. Motor neuron loss decreases output of trophic factors to muscles. Deterioration causes scar tissue that hardens the lateral aspects of the spinal cord (sclerosis: abnormal hardening of body tissue) Upper motor neurons of cortex & lower motor neurons of spinal cord degenerate. All voluntary muscles are controlled by motor neurons whose cell bodies are in. These are spinal motor neurons or lower motor neurons .
