BIOL 1F25 Lecture 1: Lecture 1
14 Sep 2016
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Document Summary
Pesticide exposure and parkinson"s disease: epidemiological evidence of association. Parkinson"s disease (pd) is a movement disorder pathologically characterized by depletion of dopaminergic (da) cell bodies in the substantia nigra pars compacta with subsequent loss of da in the nigrostriatal system. Dopaminergic: releasing or involving dopamine as a neurotransmitter. Drugs with this effect are used in the treatment of parkinson"s disease and some psychiatric disorders; some are subject to abuse. Substantia nigra: a layer of deeply pigmented gray matter situated in the midbrain and containing the cell bodies of a tract of dopamine producing nerve cells whose secretion tends to be deficient in pd. Pars compacta: part of the sn and located in the midbrain, it is the dorsal part of the gray matter. Nigrostriatal system: the ns contains about 80% of the brain"s dopamine, this pathway is involved in motor planning, dopaminergic neurons that stimulate purposeful movement. Pd is the second most common neurodegenerative disorder after alzheimer"s disease.
