BIOL 1F25 Lecture Notes - Lecture 4: Grafting, Putamen, Striatum
14 Sep 2016
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Last time: neural grafts relieve pd symptoms up to 5 months. Yes, the disease process is progressive so over time even the grafted neurons become diseased and will eventually be destroyed as well. To a certain extent, but the toxic effects of l-dopa will always continue to develop (dyskinesia, adaptability to dosage). Again, because pd is a continually degenerative condition, after a certain time period (based on the person physiologically) the grafts and l- Lindvall et al. (1994): results from two more patients. Patient 3 graft in left putamen(area in the striatum) Patient 4 graft in right putamen(area in the striatum) Anti-parkinson"s medication was kept constant during the pre-operative assessment and the first post-operative year. Both patients were given selegiline (mao-b inhibitor) beginning 15-16 months after surgery. Patient 4: l-dopa dose gradually lowered during year 2. Decreased from 50% before surgery to 20% after surgery. Decreased from 60% before surgery to 30% after surgery in first year.
