BIOL 2P02 Lecture Notes - Lecture 16: Tobacco Mosaic Virus, Dna Supercoil, Nuclear Matrix
10 Aug 2015
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Genomes pt ii & structural organization chromosome a single unit of the genome carrying many genes. Dna (of varying lengths; depending on the specific chromosome) and an approximately equal mass of proteins (eg:histones): it is visible as a morphological entity only during cell division. Why: nucleoid the structure in a prokaryotic cell that contains the genome, the dna is bound to proteins and is not enclosed by a membrane. chromatin the combination of nuclear dna and its associated proteins. Dna that are not bound to anything and are free to change supercoiled state. This can transmit tension along the dna: other supercoils are constrained: they are physically wrapped around proteins and are bound, not free to change state unless proteins are modified. Effectively its banding fingerprint: one can look at large-scale chromosomal structure for crude indication of disease in situ hybridization hybridization of the dna of cells with an single- stranded rna or dna (added by the experimenter).
