BIOL 2P03 Lecture 16: BIOL 2P03 Short Answer Questions

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If not, how can this type of exchange be facilitated: the two leaflets are usually different (e. g. external vs cytosolic faces of plasma membrane). They may have different carbohydrate contents, different types of proteins (e. g. hormone or neurotransmitter receptors face out, not in), or different types of phospholipids. These differences are related to different functional needs of the two sides: phospholipids do not flip readily because of their polar (or even charged) headgroups that are repelled by the lipid interior of the membrane. They are therefore confined to only one leaflet unless assisted by flippases", which are enzymes that catalyze transfer of phospholipids between the leaflets; categorized as flippases, floppases, and scramblases which catalyze movements in one direction, the other, or both. Depolarization is caused by the influx of na+ into the cell from the extracellular fluid (1 mark). Repolarization is caused by the movement of k+ from the cytoplasm to the extracellular fluid.

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