BIOL 2P94 Lecture Notes - Lecture 7: Limbic System, Cyclic Adenosine Monophosphate, Transporter Reversal

• School: Brock University
• Department: Biological Sciences
• Course: BIOL 2P94
• Professor: Dirk De Clercq

Document Summary

You might want to review lectures 22 (monoamines ii) and 51 (basal ganglia). Effects of stimulant drugs is the focus of this lecture: dopamine neocortex. Dopamine neurons are found in ventral tegmentum (midbrain) Basic structure of a basal ganglia loop is the same for neocortex and limbic system. Neocortex dorsal striatum (caudate) globus pallidus va thalamus . Hippocampus ventral striatum (nucleus accumbens) ventral pallidum (substantia innominata) md thalamus anterior cingulate/orbitofrontal cortex. The basal ganglia provides the connection between limbic system and dopamine neurons. Recall from basal ganglia lecture that da neurons from ventral tegementum area project to striatum and substantia nigra; therefore da neurons can affect the limbic system through its basal ganglia loop. Da neurons exert their effects by modulating postsynaptic response to glu (d1 facilitates, d2 inhibits) Serotonin neurons are found in the raphe nuclei (midbrain) and project to forebrain via the medial forebrain bundle. Serotonin or da release via stimulant drugs is nonphysiologic.