BIOL 2P97 Lecture Notes - Lecture 3: Chyme, Bicarbonate, Pancreatic Juice
28 May 2016
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Chyme is highly acidic; matches ph of the stomach: usually around ph 2. 0. If it was just dumped into our intestinal tract it would burn out our intestines. Has to be something released that counteracts and balances acid. Epithelial cells of the duodenum & pancreatic cells of pancreas release bicarbonate to neutralize the acidic chyme. Duodenum also can secrete 4 other main agents: secretin, gastric inhibitory peptide (gip, glucagon-like peptide (glp-1, cholecystokinin. Have a coordinated response between the gallbladder, pancreas, liver and stomach. Secretin and cck work to maintain this overall balance. Release of pancreatic juice into the duodenum is stimulated by: vagus nerve, local hormones. Hormones travel the blood to stimulate the pancreas to release enzyme- and bicarbonate-rich product. Secretin causes the liver to increase bile output. Cck causes the gallbladder to release stored bile: bile is necessary for fat absorption and absorption of fat-soluble vitamins (k, d, a)
