BIOL 3P30 Lecture Notes - Lecture 13: Disproportionation, Superoxide Dismutase, Nadph Oxidase
22 Aug 2015
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No with the oxygen radical creates peroxynitrate, catalyzed reactions: o o. Three sods: mnsod (mitochondrial), cuznsod (cytosol and inner. Enzymatic dismutation to hydrogen peroxide by superoxide dismutases (sod"s) membrane space), ecsod (extracellular) Mice born without mnsod are confused and die within 3 weeks- brain damage- must be important for neurons- responsible for a lot of neural degenerative diseases. Superoxide dismutase reaction: 2o - + h2 o2 + h2o2. H2o2 o2 + h2o by catalase (cat) Diffuses within cell (if in mitos, can diffuse across membranes)-not sure how but it can; careful because then it can move into the nucleus to cause dna damage. 2. and interacts with different parts of the cell. 2h2o2 o2 + 2h2o by catalase (in cytosol) by glutathione cycle (mitos and cytosol) Glutathione cycle: glutathione reductase reduced glutathione (gsh), which is oxidized to gssg. reductase uses nadph to re- reduce gssg to gsh.
