BIOL 3P30 Lecture Notes - Lecture 23: Molar Mass, Glycolysis, Nicotinamide Adenine Dinucleotide
22 Aug 2015
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Nadh oxidation (in vivo) can produce ~ -200kj/mol. Under perfect conditions 1 nadh makes 3 atp (which costs 57 kj/mol) ~85. 5% effciency. Under non-perfect conditions 1 nadh makes 2. 5 atp ~71% effcient. Respiration as a whole involves 3 sets of enzymes in independent but highly interwoven metabolic pathways. Estimated that each day the average adult needs approx. Only <0. 1mol (~50g) of atp present at any given time in entire body. What does this mean: atp must be continually recycled. It has been shown that there can be greater than a 100 fold increase in atp utilization between sleep and vigorous activity. Pathway from nadh to cytoc functions near equilibrium. 1/2 nadh + cyt c + adp + pi 1/2nad+ cyt 2+ atp. Next step in etc, that is catalyzed by complex iv, is irreversible - terminal step of electron transport onto oxygen. Reaction is candidate for kinetic control of ox/phos.
